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利用氢氧化钠作催化剂使 β 环糊精 (简称 β CD)被烯丙基修饰合成了七 (2 ,3,6 O 烯丙基 ) β 环糊精[Heptakis (2 ,3,6 O allyl) β CD]。用正交实验法考察了反应温度、反应时间、催化剂用量和修饰剂———烯丙基溴用量等因素对合成目标化合物的影响 ,得出合成七 (2 ,3,6 O 烯丙基 ) β 环糊精的最佳实验条件 :n(β 环糊精 )∶n(烯丙基溴 ) =1∶86 .92 ,n(催化剂 )∶n(烯丙基溴 ) =1∶1.0 5 2。产物经元素分析 ,IR和1 HNMR表征和确认
Heptakis (2,3,6-allyl) β-cyclodextrin was synthesized by the allyl modification of β-cyclodextrin (abbreviated as βCD) with sodium hydroxide as catalyst. β CD]. The effects of reaction temperature, reaction time, amount of catalyst and the amount of allyl bromide on the synthesis of the target compounds were investigated by orthogonal experiments. The results showed that the synthesis of hepta (2,3,6-allyl) The best experimental conditions of β-cyclodextrin: n (β-cyclodextrin): n (allyl bromide) = 1:86 .92, n (catalyst) . The product was characterized and confirmed by elemental analysis, IR and 1 HNMR