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KCl(3×10~(-2)M)引起的平滑肌收缩反应,在低浓度异搏停(VP,10~(-6)M)存在的情况下收缩减弱,在10~(-5)M 浓度时表现为微弱的舒张反应,而在高浓度(10~(-4)M)时则出现显著的舒张反应。在使用其它 Ca 拮抗剂如硫氮酮、硝苯吡啶时,也能观察到同样现象,提示对因感染和炎症等引起气道高反应性而致喘息的患者,预先给予 Ca 拮抗剂,可预防去极化引起的气管收缩发作。尽管机体的反应受体液、内分泌激素以及神经的影响很大,虽不能与体外反应
KCl (3 × 10 ~ (-2) M) induced contraction of smooth muscle contraction in the low concentration of verapamil (VP, 10 ~ (-6) M) decreased contraction in the 10 ~ (-5) M Concentration showed a weak diastolic response, and at high concentrations (10 ~ (-4) M) when the significant diastolic response. The same phenomenon can be observed when other Ca antagonists such as diazepam and nifedipine are used, suggesting that Ca antagonists may be given in advance to patients suffering wheezing caused by airway hyperresponsiveness such as infection and inflammation Prevent depolarization caused by tracheal contraction attack. Although the body’s response by the body fluids, endocrine hormones and the impact of nerve is very large, although not with the response in vitro