结肠黑变病临床上较少见 ,我们对近四年来六例患者纤维结肠镜检查中发现的结肠黑变病并取活检病理证实 ,结果 ,黑变病显示结肠粘膜呈棕色、褐色、黑色素纹状及斑片状色素沉着 ,分布可见结肠各段 ,病理示肠粘膜固有层内及肠壁神经丛周围有大量巨噬细胞 ,其胞浆内含有较多色素 ,该色素黑色素染色阳性 ,普鲁士蓝染色阴性 Colorectal melanosis clinically rare, we have in the past four years, six cases of colon colonoscopy found in patients with colorectal melanosis and biopsy confirmed the pathology, the results, melanosis showed colonic mucosa was brown, brown, melanin pattern Like and patchy pigmentation, the distribution can be seen in various segments of the colon, the pathological intestinal mucosal lamina propria and intestinal wall around the plexus a large number of macrophages, the cytoplasm contains more pigment, the pigment melanin staining positive, Prussian blue Dyed negative