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本文报道螨类接种豚鼠气管引起的肺部病变,并对5种常见螨类的致病性进行比较。发现螨类接种后6天豚鼠肺部已形成典型的结节性病灶。结节圆锥形淡黄色,直径1～5mm之间。镜下表现为细支气管炎和细支气管周围炎,肺实质内有明显的异物肉芽肿形成,炎症在螨类接种豚鼠20天时,肺部嗜酸粒细胞浸润不明显,但30或40天时则出现明显的嗜酸细胞浸润,细支气管周围小动脉受到损害,部分小动脉内可见到螨体残骸。5种常见螨炎接种于5组豚鼠可引起大致相同的病变。从而证明豚鼠可作为动物模型以供肺螨病的研究,同时也证明5种常见贮藏螨具有相同的致病性。
In this paper, we report the lung lesions induced by mites inoculation in guinea pig trachea and compare the pathogenicity of five common mites. Found 6 days after inoculation mite guinea pig lung has formed a typical nodular lesions. Nodular conical light yellow, diameter 1 ~ 5mm between. Microscopic appearance of bronchiolitis and peribronchitis, lung parenchyma with obvious foreign body granuloma formation, inflammation Mite inoculation guinea pig 20 days, pulmonary eosinophil infiltration was not obvious, but when 30 or 40 days Significant eosinophil infiltration, bronchioles around the arterioles were damaged, some of the arterioles can be seen mite body debris. Inoculation of 5 common mites into 5 groups of guinea pigs resulted in approximately the same lesions. Thus guinea pigs can be used as animal model for the study of lung mite disease, but also proved that the five common storage mites have the same pathogenicity.