作者对1983年1月至1986年6月住我院诊断为躁狂抑郁症,并符合Dunner快速循环型情感性精神病(RCAD)的27例患者中,仅18例获得为期1年半至4年半的临床随访研究,结果表明,8例有躁郁发作,其中仅1例属快速循环型发作,10例无复发。抑郁发作者对锂盐或停用抗抑郁剂有效,而躁狂发作者对卡马西平反应良好。这些病例治疗反应的差异提示RCAD可能存在生物学的异源性。 Of the 27 patients admitted to our hospital between January 1983 and June 1986 who were diagnosed with manic-depressive disorder and fulfilled Dunner’s Fast Reciprocating Emotional Psychosis (RCAD), only 18 of the 27 patients were admitted for 1 year and a half to 4 years Half of the clinical follow-up study, the results showed that 8 patients had bipolar disorder, of which only 1 case of rapid recurrent seizures, 10 patients without recurrence. Depressive patients were effective on lithium salts or antidepressants, while those on manic patients responded well to carbamazepine. The differences in the response to treatment in these cases suggest that there may be biological heterogeneity of RCAD.