PTEN基因是近年来新发现的一种抑癌基因 ,具有磷酸脂酶活性 ,可作用于脂类底物 PIP3及蛋白底物 FAK,使其去磷酸化 ,从而诱导肿瘤细胞凋亡 ,介导肿瘤细胞的 G1期阻滞 ,抑制肿瘤细胞的侵袭播散 ,促进细胞分化。 PTEN在 GBM中有较高的突变率 ,是判断 GBM患者预后的良好指标 ,同时为基因治疗胶质瘤提供一种新途径 PTEN gene is a newly discovered tumor suppressor gene in recent years. It has a phosphatase activity and can act on the lipid substrate PIP3 and the protein substrate FAK to dephosphorylate it, thereby inducing tumor cell apoptosis and mediating tumors. The G1 phase arrest of cells inhibits the invasion and spread of tumor cells and promotes cell differentiation. PTEN has a high mutation rate in GBM and is a good indicator of the prognosis of GBM patients. It also provides a new approach for gene therapy of gliomas.