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目的:以脉压(Pulse Pressure,PP)、心-踝血管指数(Cardio-ankle vascular index,CAVI)、颈动脉内中膜厚度(Intima-Media Thickness,IMT)作为评估指标,观察西药常规治疗基础上以中药潜阳合剂加载治疗对高血压病患者动脉功能的影响,为研发改善动脉硬化的新药提供临床依据。方法:对63例阴虚阳亢证型高血压病患者随机分为治疗组32例及对照组31例,两组入选患者均以常规西药治疗,治疗组另以潜阳合剂加载治疗,疗程6个月。两组患者均在首访治疗当天和二访(3个月)、三访(6个月)测量脉压、CAVI及进行阴虚阳亢证候积分评定,在首访及三访(6月)进行颈动脉IMT检测,分析各指标治疗前后的变化。结果:(1)CAVI评价:治疗3个月及6个月治疗组CAVI值减小,对照组CAVI值增大,具有极显著性差异(P<0.01,P<0.01)。(2)颈动脉IMT评价:治疗6个月治疗组颈动脉IMT值减小,对照组颈动脉IMT值增大,具有极显著性差异(P<0.01,P<0.01)。(3)脉压评价:治疗3个月后及6个月后治疗组与对照组PP值均无明显差异,差异无统计学意义(P>0.05,P>0.05)。结论:在西药基础上加载潜阳合剂治疗可以明显改善高血压病患者的阴虚阳亢症状,对于改善高血压病患者的CAVI及颈动脉内中膜厚度有一定疗效。提示在西药基础上加载潜阳合剂是改善高血压病患者动脉血管功能的一种有效治疗方法。
OBJECTIVE: To observe the routine treatment basis of western medicine by using Pulse Pressure (PP), Cardio-ankle vascular index (CAVI) and Intima-Media Thickness (IMT) On the traditional Chinese medicine plus Yang mixture loading treatment on arterial function in hypertensive patients, to provide a clinical basis for the development of new drugs to improve atherosclerosis. Methods: 63 cases of hyperthyroidism patients with yin deficiency and hyperactivity were randomly divided into treatment group (32 cases) and control group (31 cases). The two groups of patients were treated with routine western medicine. The treatment group was additionally treated with " Months. Both groups were evaluated on the first visit day and the second interview (3 months), three visits (6 months), pulse pressure, CAVI and yin deficiency and hyperactivity syndrome score. In the first visit and the third visit (June ) For carotid IMT detection, analysis of changes in the indicators before and after treatment. Results: (1) CAVI evaluation: The CAVI value decreased and the CAVI value increased in the control group at 3 months and 6 months after treatment, with significant difference (P <0.01, P <0.01). (2) Evaluation of carotid IMT: The carotid IMT decreased in the treatment group and the carotid IMT increased in the control group (P <0.01, P <0.01). (3) Pulse pressure evaluation: There was no significant difference in PP value between the treatment group and the control group after 3 months and 6 months after treatment, the difference was not statistically significant (P> 0.05, P> 0.05). Conclusion: The application of Xianyang Heji on the basis of western medicine can obviously improve the symptoms of yin deficiency and hyperactivity in hypertensive patients, and has a certain curative effect on the improvement of CAVI and carotid intima-media thickness in patients with essential hypertension. Prompted on the basis of Western medicine loaded Yang mixture is to improve arterial blood vessels in patients with hypertension an effective treatment.