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目的观察放射治疗对非小细胞肺癌(NSCLC)脑转移的疗效,探讨获得更好疗效的方法。方法2005年5月～2006年12月43例NSCLC脑转移患者接受了放射治疗,根据原发灶控制情况和有无颅外转移病灶进行分组观察,对不同生存情况进行比较。结果所有顺利完成放疗,无严重副反应和并发症发生。放疗后颅内病灶控制率为81.1%,神经系统症状缓解率为75.7%,KPS评分显著上升。全组生存时间2～36个月,中位生存时间8.6个月,半年、1年、2年生存率分别为59.5%、27.0%、5.4%。RPA1级和2级中位生存期分别为23和9.5个月,2组患者生存期有明显差异。结论3DCRT联合WBRT可有效缓解非小细胞肺癌脑转移患者症状,并延长生存期和提高生活质量。
Objective To observe the curative effect of radiation therapy on brain metastasis of non-small cell lung cancer (NSCLC) and to explore the method of obtaining better curative effect. Methods From May 2005 to December 2006, 43 NSCLC patients with brain metastases underwent radiotherapy. The patients were divided into different groups according to the control of the primary tumor and the presence or absence of extracranial metastases. Results All the successful completion of radiotherapy, no serious side effects and complications. After radiotherapy, the control rate of intracranial lesions was 81.1%, the rate of nervous system symptom relief was 75.7%, KPS score increased significantly. The overall survival time was 2-36 months, and the median survival time was 8.6 months. The half-year, one-year and two-year survival rates were 59.5%, 27.0% and 5.4% respectively. The median survival for stage 2 and stage 2 RPA was 23 and 9.5 months, respectively, with significant differences in survival between the two groups. Conclusion 3DCRT combined with WBRT can effectively alleviate the symptoms of patients with brain metastases of non-small cell lung cancer, and prolong survival and improve quality of life.