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目的:探讨低浓度一氧化氮(NO)吸入在充血性心力衰竭(CHF)中的应用价值。方法:对比观察了15例CHF患者NO吸入和二硝基异山梨醇静滴(Iso)后的急性血液动力学效应。结果:NO吸入和Iso静滴均能使平均右房压(mRAP)。平均肺动脉压(mPAP)及肺嵌压(PCWP)下降,心脏指数(CI)升高;与Iso相比,N0吸入选择性地降低肺总阻力(PCR)及肺小动脉阻力(PAR),且其作用较Iso显著;NO吸入不影响体循环压力及体循环阻力(SVR)。结论:NO吸入对CHF患者具有良好的血液动力学效应,可改善心脏作功能力。
Objective: To investigate the value of low concentration nitric oxide (NO) inhalation in congestive heart failure (CHF). Methods: The acute hemodynamic effects of NO inhalation and Iso-iso-osmolality in 15 CHF patients were compared. RESULTS: Both NO inhalation and Iso intravenous infusion resulted in an average right atrial pressure (mRAP). Mean pulmonary arterial pressure (mPAP) and pulmonary capillary pressure (PCWP) decreased and cardiac index (CI) increased. Compared with Iso, N0 inhalation selectively reduced lung total resistance (PCR) and pulmonary arterial resistance (PAR) Its role than Iso significant; NO inhalation does not affect the systemic pressure and systemic resistance (SVR). CONCLUSIONS: NO inhalation has a good hemodynamic response to CHF and improves cardiac performance.