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抗结核药物的副作用是影响疗效的重要因素之一,每一种抗结核药物都有不同程度的副作用。虽然其中大多数影响不大,不必中止治疗,但也有一些必须及时停药,从而影响全程化疗的进行。1982年Montaner等报告初治肺结核用2SHRZ_7/6～7HR_2或2S(E)HR_7/6～7HR_2治疗,因药物副作用而必须改变治疗方案者占6.5％。少数反应极为严重,甚至导致死亡。因此,对常用抗结核药物副作用的认识、判断和处理是结核病化疗的一个重要课题。本文就其具有临床重要性的几个问题综述如下。
Side effects of anti-TB drugs is one of the important factors that affect the efficacy of each anti-TB drugs have varying degrees of side effects. Although most of them have little effect, there is no need to stop the treatment, but some must be promptly discontinued, thus affecting the whole process of chemotherapy. In 1982, Montaner et al reported that patients with newly diagnosed pulmonary tuberculosis treated with 2SHRZ_7 / 6 ~ 7HR_2 or 2S (E) HR_7 / 6 ~ 7HR_2 had a 6.5% treatment regimen due to drug side effects. A handful of reactions have been extremely serious and have even led to death. Therefore, the common side effects of anti-TB drugs, judgments and treatment is an important issue of tuberculosis chemotherapy. This article summarizes several of its issues of clinical importance.