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目的 探讨肝癌血供超声观测指标与其增殖活性的关系。方法 建立兔肝ＶＸ２ 瘤模型，利用ＣＯ２ＵＳ、Ｘ－ ＤＳＡ、Ｄｏｐｐｌｅｒ ＵＳ及ＥＣＴ显示肿瘤血管，并与肿瘤的组织病理、ＤＮＡ 含量分析、ＰＣＮＡ 表达相比较。结果 经肝动脉、ＣＯ２ 造影后瘤区回声增强组肿块ＤＳＡ、Ｄｏｐｐｌｅｒ ＵＳ、ＥＣＴ血流量信号显示率较高，癌灶血窦较丰富，平均ＤＮＡ含量、ＰＣＮＡＬＩ高于回声不增强组。结论 兔肝ＶＸ２ 瘤以动脉供血为主，与种植途径无关，直径＜ ３ ．０ｃｍ 的肝恶性肿瘤超声检测可仅见动脉供血。ＣＯ２ 造影后回声增强肿块内血窦较多，荷瘤区血流信号检出率较高，瘤细胞增殖活跃，说明肿瘤血管形成对肝癌恶性生物学特征可有促进作用。
Objective To explore the relationship between ultrasound observation index and proliferative activity of liver cancer blood supply. Methods Rabbit liver VX2 tumor models were established. The tumor vessels were visualized using CO2US, X-DSA, Doppler US, and ECT, and compared with tumor histopathology, DNA content analysis, and PCNA expression. Results After hepatic arterial and CO2 imaging, tumor echo enhancement group showed higher rates of DSA, Doppler US, and ECT blood flow signals. The lesions had more sinusoids, and the average DNA content and PCNALI were higher than the echogenic group. Conclusion Rabbit hepatic VX2 tumors are mainly arterial blood supply, which has nothing to do with the planting pathway. The diameter is <3. 0cm ultrasound detection of liver malignancy can only see arterial blood supply. After echocardiography of CO2, there were more sinusoids in the tumor mass. The detection rate of blood flow signals in the tumor-bearing area was higher, and the proliferation of tumor cells was active. It indicated that tumor angiogenesis could promote the malignant biological characteristics of liver cancer.