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研究目的探讨新生儿感染性肺炎患者血清中维生素Ａ水平。研究方法病例对照研究。肺炎组和对照组各２５例，早产儿各７例，足月儿各１８例。采用高效液相色谱仪（ＨＰＬＣ）测定其维生素Ａ含量。结果肺炎组早产儿与对照组早产儿血清中维生素Ａ水平分别为０．３２±０．１２和０．６２±０．３２μｍｏｌ／Ｌ（ｔ＝２．３２２，Ｐ＜０．０５）；肺炎组足月儿与对照组足月儿维生素Ａ水平分别为０．５８±０．１２和０．８３±０．２７μｍｏｌ／Ｌ（ｔ＝２．４６３，Ｐ＜０．０２）。肺炎患者１５例（治疗组）辅以维生素Ａ治疗（１０００ＩＵ／ｄ），另外１０例肺炎患者不用维生素Ａ（对照组），治疗组病程平均为９．７天，对照组为１２．３天（Ｐ＜０．０５）。结论新生儿感染性肺炎患者血清中维生素Ａ水平显著降低，早产儿降低更为明显。辅以维生素Ａ治疗新生儿肺炎效果较好。
Objective To investigate the serum vitamin A level in neonates with infectious pneumonia. Study Methods Case Control Study. Pneumonia group and control group of 25 cases, 7 cases of premature children, 18 cases of full-term children. The vitamin A content was determined by high performance liquid chromatography (HPLC). Results The levels of serum vitamin A in preterm infants with pneumonia group and control group were 0.32 ± 0.12 and 0.62 ± 0.32μmol / L, respectively (t = 2.322, P <0.05). In pneumonia group The full-term children’s vitamin A levels in full-term infants and control subjects were 0.58 ± 0.12 and 0.83 ± 0.27 μmol / L, respectively (t = 2.463, P <0.02). 15 patients with pneumonia (treatment group) supplemented with vitamin A (1000IU / d), another 10 patients without pneumonia with vitamin A (control group), the treatment group average duration of 9.7 days, the control group was 12.3 days P <0.05). Conclusion Serum vitamin A levels were significantly decreased in neonates with infectious pneumonia and the decrease was more obvious in premature infants. Supplemented with vitamin A treatment of neonatal pneumonia better.