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大量研究报道升高的血清尿酸浓度与缺血性脑卒中(IS)发病、死亡和脑卒中后神经功能缺损有关,可能是缺血性脑卒中的独立危险因子。另有报道尿酸作为血管内最主要的抗氧化剂,在IS急性期氧化应激过程中可能起抗氧化作用,但当血清总体抗氧化能力较低时却起促氧化作用。而动物实验证据提示外源性尿酸干预与阿替普酶联合治疗可能增加急性IS溶栓治疗临床获益。目前血清尿酸浓度与IS之间的关系仍存争议。
A large number of studies reported that elevated serum uric acid concentration and ischemic stroke (IS) incidence, death and neurological deficits after stroke may be an independent risk factor for ischemic stroke. It is also reported that uric acid, as the most important anti-oxidant in blood vessels, may play an antioxidant role in the process of acute oxidative stress in IS, but it may promote the oxidation when the overall antioxidant capacity of serum is low. The animal experimental evidence suggests that exogenous uric acid intervention and alteplase combination therapy may increase the clinical benefit of acute IS thrombolytic therapy. The current relationship between serum uric acid concentration and IS is still controversial.