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子宫内膜癌(carcinoma ofendometrium)占女性生殖器恶性肿瘤的20%～30%,在美国和某些欧州国家,其发生率已跃居女性生殖道恶性肿瘤的第一位,子宫内膜癌发病原因尚未明确,随着分子生物学技术的发展,癌基因及抑癌基因在子宫内膜癌发生、发展及预后中的作用,已成为学者们研究的重点。肿瘤的发生是一个多因素、多阶段的复杂过程,以细胞失去正常调控而无限增殖为特点,是某些特殊基因突变所致,即原癌基因的异常激活和抑癌基因失活的结果。新近发现的多肿瘤抑制基因p16对细胞周期负调控作用的重要性不亚于抑癌基因p53和RB。p16与肿瘤的发生正成为人们研究的焦点。
Carcinoma of endometrium accounts for 20% -30% of female genital malignancies. In the United States and some European countries, the incidence has risen to the top of female genital tract malignancies, and the cause of endometrial cancer It is not yet clear that with the development of molecular biology techniques, the role of oncogenes and tumor suppressor genes in the occurrence, development and prognosis of endometrial cancer has become the focus of scholars’ research. The occurrence of tumors is a multi-factor, multi-stage complex process characterized by loss of normal regulation and proliferation of cells. It is caused by some special gene mutations, that is, abnormal activation of oncogenes and inactivation of tumor suppressor genes. The newly discovered multi-tumor suppressor gene p16 is as important as the tumor suppressor genes p53 and RB for its negative regulatory role in cell cycle. The occurrence of p16 and tumor is becoming the focus of research.