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文章扼要介绍了计算机辅助药物设计专家系统Ａｐｅｘ中镇痛药物数据库建立的方法和过程，同时也讨论了用药物设计专家系统Ａｐｅｘ进行全新药物设计的方法，并依据哌替啶类药物的药效团设计了一个与这一药效团相符的新化合物。
The article briefly introduces the method and process of establishing the database of analgesic drugs in computer-assisted drug design expert system Apex, and also discusses the new drug design method with the drug design expert system Apex. Based on the pharmacodynamics of the pethidine drugs Designed a new compound that matches this pharmacophore.