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（目的）分析肺癌组织多药耐药基因表达情况及其临床意义。〔方法〕运用RT－PCR方法对51例手术切除肺癌组织和相应的癌周正常肺组织进行MDRI mRNA水平检测。（结果）MDRI mRNA在正常肺组织和肺癌组织中表达阳性率分别为 13、 7％（7／51）和 43． 1％（22／51），两者差异显著（P＜0.01）。MDR1 mRNA表达与肿瘤病理类型、组织分化、TNM分期等均无明显的相关性（P＞0. 05）。〔结论〕肺组织细胞在恶变过程 MDR1 mRNA水平表达明显增加，提示 MDR1基因是肺癌标志之一，同时在肺癌先天也耐药机制中占有重要的作用。
(Objective) To analyze the expression of multidrug resistance gene in lung cancer and its clinical significance. [Methods] MDRI mRNA levels in 51 lung cancer tissues and corresponding normal lung tissues were detected by RT-PCR. (Results) The positive rate of MDRI mRNA expression in normal lung tissues and lung cancer tissues was 13, 7% (7/51) and 43. 1% (22/51), the difference between the two significant (P <0.01). There was no significant correlation between the expression of MDR1 mRNA and pathological types, histological differentiation and TNM stage (P>0.05). [Conclusion] The expression of MDR1 mRNA in malignant cells increased significantly during the malignant process, which suggests that MDR1 gene is one of the lung cancer markers. It also plays an important role in the mechanism of lung cancer congenital resistance.