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目的对不同方案抗结核固定剂量复合剂治疗新发肺结核的转归进行临床对比观察,为抗结核固定剂量复合剂的合理应用提供科学依据。方法将所观察的新发肺结核患者分为每日用药组(每日组)和隔日用药组(隔日组),每日组治疗方案为2HRZE/4HR,隔日组治疗方案为2H3R3Z3E3/4H3R3。对两组治疗转归情况进行对照观察。结果新发涂阳肺结核患者在治疗完成率、停药率、丢失率方面,每日组与隔日组比较差异无统计学意义(χ2=1.12、0.00、0.73,P>0.05);新发涂阴肺结核患者在治疗完成率、停药率、丢失率方面,每日组与隔日组比较差异无统计学意义(χ2=0.29、0.43、0.44,P>0.05);方案变更率每日组小于隔日组,差异有统计学意义(χ2=5.99,P<0.05);断药率每日组与隔日组比较,差异无统计学意义(χ2=1.56,P>0.05)。结论抗结核固定剂量复合剂每日服药和隔日服药在结核病治疗转归方面总体差异无统计学意义。由于抗结核药不良反应容易影响患者服药的依从性,因此临床工作中无论采用哪种服药方案,都应加强患者的治疗管理。
Objective To compare the clinical outcome of different programs of anti-tuberculosis fixed-dose combination in the treatment of newly-diagnosed pulmonary tuberculosis, and provide a scientific basis for the rational application of anti-tuberculosis fixed-dose combination. Methods The newly diagnosed pulmonary tuberculosis patients were divided into daily medication group (daily group) and every other day medication group (every other day group). The daily treatment regimen was 2HRZE / 4HR, and the second day treatment group was 2H3R3Z3E3 / 4H3R3. The treatment outcome of the two groups were compared. Results There was no significant difference in the completion rate, discontinuation rate and loss rate of newly-established smear-positive pulmonary tuberculosis patients between the daily group and every other day (χ2 = 1.12,0.00,0.73, P> 0.05) Tuberculosis patients in the treatment of completion rate, withdrawal rate, the loss rate, the daily group and the next day group was no significant difference (χ2 = 0.29,0.43,0.44, P> 0.05); program change rate daily group less than every other day group , The difference was statistically significant (χ2 = 5.99, P <0.05); drug-withdrawal rate between the daily group and every other day group, the difference was not statistically significant (χ2 = 1.56, P> 0.05). Conclusion There is no statistically significant difference between the daily dose of anti-tuberculosis fixed-dose combination and the medication taken every other day in the treatment of tuberculosis. Because of adverse reactions to anti-TB drugs easily affect the compliance of patients taking medication, so no matter what kind of medication regimen used in clinical work, should strengthen the patient’s treatment management.