大剂量氨甲喋呤 (ＨＤ—ＭＴＸ)化疗时常引起肝肾功能和皮肤粘膜损害 ,常规应用甲酰四氢叶酸钙 (ＣＦ)肌注减少副反应 ,我们在临床实践中发现减少ＣＦ肌注剂量同时用ＣＦ漱口解救取得良好结果 ,现报告如下。临床资料1 .对象我院儿科急性淋巴细胞白血病(ＡＬＬ)和非霍奇金氏淋巴 High-dose methotrexate (HD-MTX) chemotherapy often cause liver and kidney function and skin and mucosal damage, routine use of leucovorin (CF) intramuscular injection to reduce side effects, we found in clinical practice to reduce CF intramuscular dose while using CF Mouthwash rescue achieved good results, are as follows. Clinical data 1 Subjects Pediatric acute lymphoblastic leukemia (ALL) and non-Hodgkin’s lymph