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目的 通过观察抗氧化剂与自由基清除剂对大鼠亚硒酸钠性白内障的口服预防作用 ,探讨白内障的防治新途径。方法 实验分为正常对照组、亚硒酸钠诱导发病组及口服预防组。亚硒酸钠诱导发病组系给 11～ 13日龄的大鼠皮下注射亚硒酸钠 ,首次剂量为 6umol/Kg体重 ,间日 1次 ,逐次递增 1umol/Kg体重 ,连续 6次。口服预防组则为注射亚硒酸钠诱导发病组的同时口服抗氧化剂与自由基清除剂。通过晶状检验 ,观察是否发生白内障比较各组间差异。结果 口服预防组白内障的发生率为 19.2 %～ 2 8%。与诱导发病组的 94 .9%的白内障发生率相比 ,差异有极显著意义。结论 抗氧化剂与自由基清除剂通过口服能有效地防止大鼠亚硒酸钠性白内障的发生
Objective To observe the oral preventive effects of antioxidants and free radical scavengers on sodium selenite-induced cataract in rats and to explore new ways of prevention and treatment of cataract. Methods The experiment was divided into normal control group, sodium selenite induced disease group and oral preventive group. Sodium selenite-induced pathogenesis rats were subcutaneously injected with sodium selenite at 11-13 days of age. The first dose was 6umol / kg of body weight, once daily with 1umol / kg of body weight successively for 6 times. Oral prophylaxis group was injected with sodium selenite in the pathogenesis group while oral anti-oxidants and free radical scavengers. Through the crystal test, observe the occurrence of cataracts differences between groups. Results The incidence of cataract in oral preventive group was 19.2% -28%. Compared with 94.9% incidence of cataract in the induced group, the difference was significant. Conclusion Antioxidants and free radical scavengers can effectively prevent the occurrence of sodium selenite cataract in rats through oral administration