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目的观察地衣芽胞杆菌活菌制剂(整肠生胶囊)联合庆大霉素预防伊立替康(irinotecan,CPT-11)所致腹泻的疗效。方法31例接受含伊立替康方案化疗的晚期癌症患者,采用自身随机交叉对照的方法,分别于2个治疗周期接受化疗(对照组)、化疗+整肠生胶囊+庆大霉素(预防组),比较腹泻及其他不良反应的差异。结果31例患者在2个治疗周期中,预防组较对照组腹泻发生率有显著降低(腹泻发生率分别为48.4%vs 61.3%,P<0.05;3/4级腹泻发生率分别为9.7%vs 16.1%,P<0.05),且减少合并用药;同时骨髓抑制、食欲减退、恶心呕吐的发生率也有所降低(P<0.05),而2组便秘、肝肾功能异常差异无显著性。结论地衣芽胞杆菌活菌制剂联合庆大霉素能有效预防伊立替康所致腹泻。
Objective To observe the efficacy of Geobacillus licheniformis preparation (Zhengchang Sheng Capsule) combined with gentamicin in preventing diarrhea induced by irinotecan (CPT-11). Methods Twenty-one patients with advanced cancer receiving irinotecan regimen were randomly divided into two groups: chemotherapy (control group), chemotherapy + Changchang Capsule + gentamicin (preventive group ) To compare the differences in diarrhea and other adverse reactions. Results The incidence of diarrhea in the prevention group was significantly lower than that in the control group (48.4% vs 61.3%, P <0.05, respectively) in 31 patients in two treatment cycles. The incidence of 3/4 diarrhea was 9.7% vs 16.1%, P <0.05). The incidences of myelosuppression, loss of appetite and nausea and vomiting were also decreased (P <0.05). There were no significant differences in constipation and liver and kidney dysfunction between the two groups. Conclusion Bacillus licheniformis combined with gentamicin can effectively prevent irinotecan-induced diarrhea.