论文部分内容阅读
鬼臼毒素作为鬼臼属植物的主要活性成分 ,已经有广泛的研究报道。其同系物及衍生物具有很强的抗肿瘤活性。依托泊甙、替尼泊甙已经成功地用于临床抗肿瘤治疗。优化结构、寻找新的鬼臼毒素类化合物资源替代品 ,已成为当前进一步研究的主要方向。
Podophyllotoxin has been widely reported as the main active component of Podophyllum. Its homologues and derivatives have strong anti-tumor activity. Etoposide, teniposide has been successfully used in clinical anti-cancer treatment. Optimizing the structure and finding new substitutes of podophyllotoxin resources has become the main direction of further research.