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[目的]研究不同加工工艺对30%氰氟虫腙.三唑磷悬乳剂的物理稳定性影响。[方法]采用3种工艺制备悬乳剂。工艺A:各组分混合后经高速剪切、砂磨后制成悬乳剂;工艺B:先分别配制氰氟虫腙悬浮剂、三唑磷水乳剂,然后在高速剪切的条件下将前者加入到后者中制得悬乳剂;工艺C:先配制氰氟虫腙悬浮剂,在高速剪切条件下将三唑磷原药与乳化剂的混合物加入到悬浮剂中,剪切均匀后即得悬乳剂。通过测定悬乳剂的粒径、析水率、悬浮率及采用Turbiscan Lab扫描,分析加工工艺对悬乳剂稳定性的影响。[结果]采用工艺A、B、C均可以制备粒径小的悬乳剂;在贮存期间,工艺A制备的悬乳剂粒径增幅最大,工艺C制备的悬乳剂粒径增幅最小;3种工艺制备的悬乳剂其析水率、悬浮率均表现出显著性差异,其中工艺C制备的悬乳剂悬浮率最高、析水率最低,物理稳定性好。Turbiscan Lab稳定性分析仪分析结果也显示工艺C物理稳定性最好。[结论]采用工艺C配制的悬乳剂物理稳定性最佳;加工工艺是影响悬乳剂物理稳定性的重要因素。
[Objective] The research aimed to study the influence of different processing technologies on the physical stability of 30% metaflumizone triazophos suspension. [Method] Three kinds of techniques were used to prepare suspoemulsion. Process A: Each component is mixed and then sheared by high speed shearing and then sanding; Process B: First, cyanofenozole suspending agent and triazophos emulsion are respectively prepared, and then the former is cut under high speed shearing conditions Added to the latter in the preparation of suspoemulsion; Process C: first prepared by hydralazine suspending agent, under high shear conditions triazophos original drug and emulsifier mixture was added to the suspension agent, after the shear is uniform Suspension emulsion. Through the determination of the particle size, the rate of water suspension, the suspension rate and the Turbiscan Lab scanning, the influence of the processing technology on the stability of the suspoemulsion was analyzed. [Result] The suspension emulsions with small particle size could be prepared by using the processes A, B and C. During the storage, the particle size of the emulsion prepared by the process A increased the most, and the particle size of the suspension prepared by the process C had the smallest increase. The suspending agent showed significant differences in the water-splitting rate and the suspending rate. Among them, the suspending agent prepared by the process C had the highest suspension rate, the lowest water-splitting rate and good physical stability. Turbiscan Lab stability analyzer analysis also showed that the best physical C process stability. [Conclusion] The physical stability of the emulsion prepared by the process C was the best. The processing technology was an important factor affecting the physical stability of the suspoemulsion.