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目的:研究P504s、p63和HMWCK在前列腺病变鉴别诊断中的应用。方法:对93例不同的前列腺病变标本采用免疫组织化学方法观测P504s、p63和HMWCK的表达。结果:P504s在前列腺癌中高表达,正常前列腺组织基本不表达,在前列腺上皮内瘤变(PIN)及不典型增生(AAH)组织中可散在弱表达;p63和HMWCK正常前列腺组织表达,而在前列腺癌则没有或少量表达。结论:采用三种组合式抗体在同一张切片中直接观察各种病变,有助于前列腺病变的诊断和鉴别诊断。
Objective: To study the application of P504s, p63 and HMWCK in the differential diagnosis of prostatic lesions. Methods: The expression of P504s, p63 and HMWCK in 93 specimens of different prostatic lesions were observed by immunohistochemistry. Results: P504s was overexpressed in prostate cancer and normal prostate tissue was not expressed. P504s was weakly expressed in PIN and atypical hyperplasia (AAH) tissues; p63 and HMWCK were normal in prostate tissue, Cancer is not or small expression. Conclusion: It is helpful to diagnose and differentiate prostatic diseases directly by using three kinds of combined antibodies in the same slice.