应用聚合酶链反应0寡核苷酸探针（PCR－SSO）斑点杂交技术，对222名辽宁地区汉族人群无关个体进行HLA－A基因检测，研究中国辽宁地区汉族群体的HLA－A座位基因分布状况。共检出HLA－A等位基因24个，其中以等位基因HLA－A0201最为常见，频率为0．2635；依次是2402101和1101，等位基因频率分别为0．1847和0．1262.理论杂合度为87％，个人鉴别机率为92％，非父排除率为73．3％。在中国辽宁汉族中检出73种基因型，对观察值和期望值进行X2检验，符合Hardy－Weinberg平衡定律（x2＝6．28，df＝9，0．5＜P＜0．75）。家系分析结果表明按照孟德尔方式遗传。提出的中国辽宁汉族HLA－A等位基因的遗传基因情况，可用于法医学个人识别和亲子鉴定。人类学，HLA相关疾病，及器官移植研究。 HLA-A gene was detected in 222 Han unrelated individuals in Liaoning province by PCR-SSO dot blot hybridization. HLA-A locus distribution in Han population in Liaoning Province, China situation. A total of 24 HLA-A alleles were detected, of which HLA-A0201 was the most common allele at a frequency of 0.2635, followed by 2402101 and 1101 alleles at 0.1847 and 0.1262, respectively Heterozygosity was 87%, personal identification rate was 92%, non-parent exclusion rate was 73.3%. A total of 73 genotypes were detected in Liaoning Han nationality in China. The observed and expected X2 values ​​were tested by Hardy-Weinberg equilibrium (x2 = 6.28, df = 9, 0.5