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对10例白细胞减少和11例正常的系统性红斑狼疮病人,服泼尼松1mg·kg~(-1)·d~(-1),观察服药前后白细胞变化。结果两组服药前白细胞分别为(2.59±0.85)×10~9/L和(6.23±1.91)×10~9/L,服药后1周时均明显升高,第3周到达高峰,分别为(8.84±1.66)×10~9/L和(15.94±2.73)×10~9/L。但A组上升不如B组上升明显。说明SLE伴白细胞减少者骨髓抑制,代偿功能降低和服用激素后血管边缘池、骨髓贮备池白细胞减少,易引起感染,一旦感染难以控制。
Prednisone 1 mg · kg -1 · d -1 was administered to 10 patients with leukopenia and 11 normal systemic lupus erythematosus patients. Changes of leukocytes before and after treatment were observed. Results Before treatment, leukocytes in the two groups were (2.59 ± 0.85) × 10 ~ 9 / L and (6.23 ± 1.91) × 10 ~ 9 / L respectively, both increased significantly at 1 week and peaked at 3 weeks ± 1.66) × 10 ~ 9 / L and (15.94 ± 2.73) × 10 ~ 9 / L. However, the increase in group A was not as obvious as that in group B. SLE with leukopenia explain myelosuppression, reduced compensatory function and taking the hormone after the marginal pool of blood vessels, bone marrow pool leukopenia, easily lead to infection, once the infection is difficult to control.