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肌萎缩侧索硬化 (ALS)的发病机制可能与兴奋性氨基酸 ,特别是谷氨酸的毒性作用有关。我们分析比较了ALS病人和神经系统健康的受试者脑脊液中谷氨酸的水平 ,以探讨由谷氨酸介导的“兴奋毒性”是否在ALS的发病机制中具有重要作用。1 对象和方法 :(1 )ALS组 :共 1 5例 ,男 9例 ,?
The pathogenesis of amyotrophic lateral sclerosis (ALS) may be related to the toxic effects of excitatory amino acids, especially glutamate. We analyzed and compared the levels of glutamate in cerebrospinal fluid of subjects with ALS and neurological health to investigate whether glutamate-mediated “excitotoxicity” plays an important role in the pathogenesis of ALS. 1 objects and methods: (1) ALS group: a total of 15 cases, 9 males,?