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在正常细胞与白血病细胞之间以及在不同类型的白血病细胞之间,细胞浆和细胞膜中的酶含量和同功酶构型有重大差异。这些酶标记可望有助于白血病和淋巴瘤的正确诊断和有效治疗。终末脱氧核甙酸转移酶(TdT)是一种独特的DNA聚合酶,它可复制脱氧核甙酸序列,而无须核酸模板信息。正常时,高浓度TdT几乎仅见于胸腺中,但McCaffrey等报道,在大多数急性原始淋巴细胞性白血病(ALL)病例和某些有母细胞转化的慢性粒细胞性白血病(CGL)病例中,可检出高TdT
There is a significant difference in enzyme content and isozyme configuration between normal and leukemic cells and between different types of leukemic cells in the cytoplasm and in the plasma membrane. These enzyme markers are expected to help the correct diagnosis and effective treatment of leukemia and lymphoma. Terminal deoxynucleotidyl transferase (TdT) is a unique DNA polymerase that replicates deoxyribonucleotide sequences without the need for nucleic acid template information. Normally, high concentrations of TdT occur almost exclusively in the thymus, but McCaffrey et al. Reported that in most cases of acute lymphoblastic leukemia (ALL) and in some cases of chronic myeloid leukemia (CGL) with blastocysts, High TdT detected