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为探讨衰老与细胞色素P4503A（CYP3A）的活性是否有关，本文用红霉素N-脱甲基酶活性测定法分别检测了SAM-R1、SAM-P1和SAM-P8三组衰老加速鼠（SAM）中肝微粒体细胞色素P4503A的活性，每组动物分为7、13、36周龄组。结果发现SAM－P1和SAM－P8组中随年龄增长，CYP3A的活性均降低。13周时，SAM－P1组CYP3A活性下降39．5％（t＝2．525，P＜0．05）；SAM－P8组CYP3A活性下降约43．7％（t＝2．24，P＜0．05），36周与13周组相比，SAM－P1组CYP3A活性下降约71．3％（t＝2．84，P＜0．02），SAM－P8组中降低约62．9％（t＝3．21，P＜0．01），SAM－R1组中7－13周时降低约13．6％，13周至36周降低约38．2％，t＝2．37．P＜0．05。提示细胞色素P4503A对衰老有重要影响作用。
In order to explore whether aging is related to the activity of cytochrome P4503A (CYP3A), three groups of SAM-R1, SAM-P1 and SAM-P8 accelerated aging rats were tested by erythromycin N-demethylase activity assay ) In liver microsomal cytochrome P4503A activity, each group of animals were divided into 7, 13, 36 weeks of age group. The results showed that, with age, SAM-P1 and SAM-P8 group, CYP3A activity were reduced. The activity of CYP3A in SAM-P1 group decreased by 39.5% (t = 2.525, P <0.05) at 13 weeks, and decreased by 43.7% (P < 0.05). The CYP3A activity in SAM-P1 group decreased by 71.3% (t = 2.84, P <0.02) compared with that in 13 weeks group in 36 weeks, and decreased by 62.9% in SAM-P8 group (T = 3.21, P <0.01). In the SAM-R1 group, there was a decrease of about 13.6% at 7-13 weeks and a decrease of about 38.2% at 13 weeks to 36 weeks, t = 2.37. P <0.05. Tip cytochrome P4503A has an important impact on aging.