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目的探讨大剂量维生素C联合利巴韦林与地塞米松治疗小儿急性病毒性心肌炎对患儿超声心动图的影响。方法将184例病毒性心肌炎患儿随机分为试验组和对照组各92例。试验组给予大剂量维生素C联合利巴韦林与地塞米松治疗,对照组仅给予大剂量维生素C联合利巴韦林治疗。对比观察2组左心房直径(LAD)、舒张末直径(LVDD)及左室收缩末(LVSD)、右心室舒张期直径(RVDD),室间隔厚度(IVSD)、右心室流出道直径(RVOT)和左室射血分数(LVEF)检测值。结果治疗后2组LAD、LVDD、LVSD、RVDD、IVSD和RVOT低于对照组,而LVEF高于对照组,且试验组患者变化幅度远大于对照组,差异均具有统计学意义(P<0.05)。结论大剂量维生素C联合利巴韦林和地塞米松治疗可有效保护小儿急性病毒性心肌炎患儿的心脏结构。
Objective To investigate the effects of high-dose vitamin C combined with ribavirin and dexamethasone on echocardiography in children with acute viral myocarditis. Methods 184 children with viral myocarditis were randomly divided into experimental group and control group of 92 cases. The experimental group was given high-dose vitamin C combined with ribavirin and dexamethasone treatment, the control group was given only high-dose vitamin C combined with ribavirin treatment. The left atrium diameter (LAD), end diastolic diameter (LVDD), left ventricular end-systole (LVSD), right ventricular diastolic diameter (RVDD), interventricular septum thickness (IVSD) and right ventricular outflow tract diameter (RVOT) And left ventricular ejection fraction (LVEF) measurements. Results The LVE, LVDD, LVSD, RVDD, IVSD and RVOT in the two groups after treatment were lower than those in the control group, while the LVEF in the two groups were significantly higher than those in the control group (P 0.05) . Conclusion High-dose vitamin C combined with ribavirin and dexamethasone can effectively protect the heart of children with acute viral myocarditis.