非抑制性类胰岛素是存在于血液中的一类因子。在试管内进行胰岛素活性模拟实验,发现这些因子不被抗胰岛素抗体所中和。现已知血液中存在三种不同形式的 NSILA,即 NSILP、IGF_1、和 IGF_2。据认为,促生长因子 C 作用完全相同于 IGF_1。可通过肾组织抑制胰岛素降解。NSILA 的制剂通过肝细胞浆膜和胰岛素蛋白酶亦可抑制胰岛素降解。胰岛素蛋白酶是从鼠的骨骼肌中分离出的一种水解酶。该酶也在人的肌肉和皮下脂肪中发现。据 Paulsen 等人认为,这种酶的作用是在病人的皮下注射处破坏胰岛素, Non-inhibitory insulin is a type of factor present in the blood. Insulin activity was simulated in vitro and found that these factors were not neutralized by anti-insulin antibodies. It is known that there are three different forms of NSILA in blood, namely NSILP, IGF1, and IGF2. It is thought that growth factor C acts exactly the same as IGF_1. Insulin degradation can be inhibited by kidney tissue. NSILA’s formulation also inhibits insulin degradation by the hepatic plasma membrane and insulin protease. Insulin protease is a hydrolase isolated from the skeletal muscle of mice. The enzyme is also found in human muscle and subcutaneous fat. According to Paulsen et al., The role of this enzyme is to destroy insulin at the patient’s subcutaneous injection site,