AIM:To assess Helicobacter pylori(Hpylon)seroprevalence in a cohort of Greek patients with lung cancer. METHODS:Seventy-two lung cancer patients(55 males and 17 females,aged 58.2±11.7 years)and 68,age and gender-matched,control subjects were enrolled.All subjects underwent an enzyme-linked immunosorbent assay IgG serologic test for Hpylori diagnosis. RESULTS:A correlation between age and HpyloriIgG level was detected for both lung cancer patients(r=0.42, P=0.004)and controls(r=0.44,P=0.004).Seropositivity for Hpyloridid not differ significantly between patients with lung cancer and controls(61.1% vs 55.9%,P>0.05). Concerning the mean serum concentration of IgG antibodies against Hpylori,no significant difference between the two groups was detected(32.6±19.1 vs 27.4±18.3 U/mL, P>0.05). CONCLUSION:No significant association between Hpylori infection and lung cancer was found. AIM: To assess Helicobacter pylori (Hpylon) seroprevalence in a cohort of Greek patients with lung cancer. METHODS: Seventy-two lung cancer patients (55 males and 17 females, aged 58.2 ± 11.7 years) and 68, age and gender- matched, control subjects were enrolled. All subjects underwent an enzyme-linked immunosorbent assay IgG serologic test for Hpylori diagnosis. RESULTS: A correlation between age and Hpylori IgG level was detected for both lung cancer patients (r = 0.42, P = 0.004) and controls = 0.44, P = 0.004) .Seropositivity for Hpyloridid ​​not differ significantly from patients with lung cancer and controls (61.1% vs 55.9%, P> 0.05). Concerning the mean serum concentration of IgG antibodies against Hpylori, no significant difference between the two groups were detected (32.6 ± 19.1 vs 27.4 ± 18.3 U / mL, P> 0.05). CONCLUSION: No significant association between Hpylori infection and lung cancer was found.