糖蛋白为胆石的主要成份之一,本文概述了从临床、生化、组织学、细胞生物学、生物物理学等方面对其研究的成果;(一)糖蛋白参与胆石的形成过程;(二)从分子水平上看,糖蛋白有与胆红素进行疏水结合的能力;(三)胆道系统中有多种来源的自由基反应;(四)胆道系统中的糖蛋白有清除自由基作用;(五)自由基可刺激胆道粘膜上皮分泌糖蛋白增加;(六)糖蛋白在与自由基反应时,自身裂解,其粘弹性丧失. Glycoprotein is one of the main components of gallstone. This paper summarizes the results of its research in clinical, biochemistry, histology, cell biology and biophysics; (1) glycoprotein participates in the formation of gallstone; (2) At the molecular level, glycoproteins have the ability to bind hydrophobicly to bilirubin; (iii) there are multiple sources of free radical reactions in the biliary system; (d) glycoproteins in the biliary system have the effect of scavenging free radicals; E) free radicals can stimulate the secretion of biliary epithelial glycoprotein increased; (vi) glycoprotein in the reaction with free radicals, their lysis, the loss of its viscoelasticity.