本文建立家兔心肌缺血再灌注模型，用透射电镜观察心肌细胞超微结构的变化以及应用硝苯吡啶（心痛定）的影响，结果对照组显示超微结构明显破坏，尤其是线粒体和细胞膜系统破坏严重。而用药组心肌细胞改变轻微，表明钙拮抗药能减轻心肌缺血再灌注时细胞超微结构的损伤。 Myocardial ischemia-reperfusion model was established in this paper. The ultrastructure of myocardial cells was observed by transmission electron microscope and the effect of nifedipine (nifedipine) was observed. The results showed that the control group showed obvious destruction of ultrastructure, especially mitochondria and cell membrane system Seriously damaged. However, the changes of myocardial cells in the medication group were slight, indicating that calcium antagonists can reduce the ultrastructure damage during myocardial ischemia-reperfusion.