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研究表明,大肠癌(colorectalcancer ,CRC )的发生是1个多因素多步骤的过程,是机体的内因与环境的外因相互作用的结果。其中错配修复基因的改变与遗传性和散发性结直肠癌的基因不稳定性有关。本文就错配修复基因异常导致大肠癌的机制及其诊断与治疗的最新研究进展做一综述。1
Studies have shown that the occurrence of colorectal cancer (CRC) is a multi-factor, multi-step process, which is the result of external factors of the body’s internal environment and environment. Among them, the changes of mismatch repair genes are related to genetic instability of hereditary and sporadic colorectal cancer. This article reviews the mechanism of mismatch repair gene anomalies leading to colorectal cancer and the latest research progress of its diagnosis and treatment. 1