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食道静脉曲张出血患者的发病率与死亡率,几十年来几乎不变,目前人们对心得安治疗门脉性高血压十分感兴趣。 心得安在肝硬化病人血中药物的半衰期延长,其治疗门脉性肝硬化静脉曲张的作用主要在于减少肝血流和心脏指数,促使门脉压力下降,还可能对门静脉系统产生间接的降压作用。Lebrec等首先用口服心得安40～180mg,每日2次(剂量增至脉搏减慢25％为止),给8例门脉高压静脉曲张的出血病人治疗1个月,证实由于心脏指数降低,促使内脏静脉血流减少,从而改善肝静压楔压和肝静脉压,治疗后无1例再次出血。后来又选择24例类似
Esophageal variceal bleeding in patients with morbidity and mortality, almost unchanged for decades, people are now on the treatment of portal hypertension is very interested. Experience in the liver of patients with cirrhosis of the blood half-life of the drug, its treatment of portal vein cirrhosis varicose veins main effect is to reduce the hepatic blood flow and cardiac index, to promote portal pressure drops, but also may have an indirect antihypertensive portal system effect. Lebrec and other first with oral propranolol 40 ~ 180mg, 2 times a day (dose increased to 25% of the pulse so far) to 8 cases of bleeding in patients with portal hypertension varicose vein treatment for 1 month, confirmed that due to lower cardiac index, prompted Visceral venous blood flow decreased, thereby improving hepatic hydrostatic wedge pressure and hepatic venous pressure, no bleeding after treatment in 1 case. Later chose 24 cases similar