Ｖ Ａ Ｔ Ｐａｓｅ 存在于所有已知的真核生物中， 有极为重要的生理作用． 近几年来， 对 Ｖ Ａ Ｔ Ｐａｓｅ 的结构、功能和调控机制的研究进展很快， 对复合体的组装有了进一步的认识． 对 Ｖ Ａ Ｔ Ｐａｓｅ 的主要亚基已经完成序列测定及分析， 对各亚基生理功能也进行了较为深入的研究． 生物化学及分子生物学工作揭示： 生物体内以多种方式对编码 Ｖ Ａ Ｔ Ｐａｓｅ 主要亚基的基因表达和该酶的活力进行调控 V  A T Pase exists in all known eukaryotes, has a very important physiological role. In recent years, the research on the structure, function and regulatory mechanism of V-ATPase has progressed rapidly, and further understanding of the assembly of the complex has been made. The major subunits of VATPase have been sequenced and analyzed, and the physiological functions of each subunit have also been studied in more depth. Biochemistry and molecular biology have revealed that in vivo there are many ways in which genes encoding the major subunit of V-ATPase and gene activity of the enzyme can be regulated