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去氢表雄酮硫酸酯钠盐(DHA-S)作为宫颈熟化剂已应用于临床,治疗子宫颈管成熟不全,减少过期产和缩短产程~[1]。我国产科临床也已开始试用。其结构式见下。 妊娠家兔静脉注射DHA-S后,宫颈胶原酶活性增高,胶原纤维分解断裂~[2]。幼大鼠和妊娠末期大鼠注射DHA-S后,子宫、宫颈重量及其含水量都相应有所增加,对照药物雌激素也具有上述作用~[3.4].产妇用药后,血浆和宫颈组织内雌二醇水平均明显增高~[5]。提示雌激素参入了DHA-S的促子宫颈管熟
Dehydroepiandrosterone sulfate sodium salt (DHA-S) as a cervical ripening agent has been used in clinical treatment of cervical canal maturity, reduce obsolescence and shorten the labor process [1]. Obstetrics and gynecology in China has also begun trial. The structural formula below. After intravenous injection of DHA-S into rabbits, cervical collagenase activity increased, collagen fibers broke down ~ [2]. After injection of DHA-S into the young rats and late gestation rats, the uterine, cervical weights and their water contents increased correspondingly, and the control drug estrogen also had the above mentioned effect. [3.4] Estradiol levels were significantly increased ~ [5]. Tip estrogen into the DHA-S of the cervical ripening