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目的总结中国大陆1964年至2013年报道的李斯特菌病(LD)病例,分析其临床与流行病学特征。方法通过计算机结合手工检索我国1964年至2013年来报道李斯特菌病的文献资料,统计各李斯特菌病例的临床与流行病学信息,并进行分析。结果总结中国大陆1964年至2013年报道的LD相关文献121篇,LD病例256例,其中非围生期病例122例,新生儿86例,围生期孕妇48例;局灶感染39例,血液系统感染103例,中枢神经系统感染103例,11例未提供感染部位信息。多为散发(252例),仅1起爆发引起4例患者感染。青霉素耐药率18.9%,总体死亡率30.8%,新生儿组死亡率52.6%,中枢神经系统感染者死亡率39.1%。结论李斯特菌病特别是新生儿感染者或中枢神经系统感染者病情严重,死亡率较高,应加强预防治疗。
Objective To summarize the cases of Listeriosis (LD) reported in mainland China from 1964 to 2013 and analyze the clinical and epidemiological characteristics. Methods The data of listeriosis reported in China from 1964 to 2013 were retrieved by computer and hand-searched, and the clinical and epidemiological information of each Listeria were statistically analyzed. Results There were 121 LD related articles reported from mainland China from 1964 to 2013, 256 cases of LD, including 122 cases of non-perinatal period, 86 cases of neonatal period, 48 cases of perinatal period, 39 cases of focal infection, 103 cases of systemic infection, 103 cases of central nervous system infection, 11 cases did not provide information on the location of the infection. Mostly disseminated (252 cases), only one outbreak caused 4 patients infected. The rate of penicillin resistance was 18.9%, the overall mortality rate was 30.8%, the neonatal mortality rate was 52.6% and the central nervous system infection rate was 39.1%. Conclusion Listeriosis, especially neonatal infection or central nervous system infection, is seriously ill and has a high mortality rate. Prevention and treatment should be strengthened.