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目的：观察生长抑素（ｓｏｍａｔｏｓｔａｔｉｎ）对食管静脉曲张破裂大出血的止血效果。方法：３０例肝硬化食管静脉曲张破裂大出血病人随机分成２组，生长抑素组（男性１４例；年龄４５±ｓ１０ａ）用生长抑素２５０μｇ，ｉｖ后，以２５０μｇ／ｈ的速度持续静脉滴注６０～９６ｈ。加压素组（男性１４例，女性２例；年龄４６±７ａ）用加压素（ｖａｓｏｐｒｅｓｉｎ）１０Ｕｉｖ后，以０．４Ｕ／ｍｉｎ的速度维持静滴４８～９６ｈ。结果：生长抑素组止血率为８６％（１２／１４），死亡率７％（１／１４）；加压素组止血率为５０％（８／１６），死亡率为５０％（８／１６）。结论：生长抑素是一种治疗肝硬化食管静脉曲张破裂大出血的有效止血药。
Objective: To observe the hematopoietic effect of somatostatin on hemorrhagic esophageal variceal bleeding. Methods: Thirty patients with cirrhosis and esophageal variceal bleeding were randomly divided into two groups. Patients in the somatostatin group (14 males; age 45 ± s10a) were treated with 250μg / h of somatostatin and iv at a rate of 250μg / h 60 ~ 96h. Vasopressin group (14 males, 2 females; age 46 ± 7a) was treated with vasopressin 10Uiv, and the infusion rate was maintained at 0.4U / min for 48-96h. Results: The rate of hemostasis in the somatostatin group was 86% (12/14) and the mortality rate was 7% (1/14). The hemostatic rate in the somatostatin group was 50% (8/16) and the mortality rate was 50% (8 / 16). Conclusion: Somatostatin is an effective hemostatic agent for the treatment of hemorrhagic esophageal varices with cirrhosis.