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[目的]探讨脊髓亚急性联合变性的临床特点,寻找理想的治疗方法。[方法]总结11例患者的临床资料,进行分析。[结果]表现双下肢无力并行走不稳5例(5/11),深感觉障碍11例(11/11),血清VitB12浓度降低8例(8/11),脊髓MRI6例(6/8),可见脊髓后索异常信号,应用VitB12治疗患者均有不同程度的好转。[结论]深感觉障碍是脊髓亚急性联合变性的重要体征,VitB12检测常降低,脊髓MRI扫描可以辅助诊断,VitB12治疗有效。
[Objective] To explore the clinical features of spinal cord subacute combined degeneration and find the ideal treatment. [Methods] The clinical data of 11 patients were summarized and analyzed. [Results] Five patients (5/11), 11 patients with deep sensory disturbances (11/11), 8 patients with decreased serum concentration of VitB12 (8/11), 6 patients with spinal cord MRI (6/8) , Visible abnormal signal of spinal cord after the application of VitB12 treatment patients have varying degrees of improvement. [Conclusion] Deep sensory disturbance is an important sign of subacute combined degeneration of spinal cord. VitB12 detection often decreases. Spinal MRI scan can be used to diagnose and VitB12 is effective.