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目的评价金川牌健生啤酒作为保健食品的安全性,为其后续试验提供毒理学安全依据。方法依据卫生部《保健食品检验与评价技术规范》,通过小鼠经口急性毒性试验、致突变试验、大鼠30d喂养试验对金川牌健生啤酒进行检测。结果小鼠经口LD50>21.5g/kg.BW,属无毒级物质;致突变试验结果为阴性;大鼠30d喂养试验表明各剂量组体重增长、食物利用率、脏体比、血液学及血清生化指标与对照组比较差异均无统计学意义(P>0.05)。病理检查主要脏器未发现与实验有关的病理性改变。结论从食品毒理学安全性角度评价,金川牌健生啤酒无毒、无致突变作用,因此从试验结果推断长期饮用金川牌健生啤酒是安全的。
Objective To evaluate the safety of Jinchuan brand draft beer as a health food and provide toxicological basis for its follow-up test. Methods According to the Ministry of Health “health food inspection and evaluation technical specifications”, through oral acute toxicity test in mice, mutagenicity test, 30d rat feeding test Jinchuan card draft beer. Results The oral LD50> 21.5g / kg.BW in mice was a non-toxic substance. The results of mutagenicity test were negative. The rats fed with 30d showed that body weight gain, food utilization rate, body weight ratio, hematology, There was no significant difference between the serum biochemical indexes and the control group (P> 0.05). Pathological examination of the main organs found no experimental pathological changes. Conclusion From the perspective of food toxicology safety evaluation, Jinchuan brand draft beer is non-toxic and non-mutagenic. Therefore, it is inferred from the test results that it is safe to drink Jinchuan brand draft beer in long term.