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为了评价国产钩端螺旋体外膜疫苗的流行病学效果 ,于 1998年 6～ 10月 ,用队列研究和病例对照研究等方法在钩体病流行区 5～ 6 0岁农业人口中 ,观察比较接种组和对照组钩体发病情况。队列研究显示 ,钩体外膜疫苗对同血清群钩体的保护率为 75 17% ,效果指数为 4 0 3。 1∶2配对调查的疫苗保护率为 81 2 5 % ,1∶3配对结果为 73 33%。用筛选法估计的疫苗效果为 75 %。不同研究方法的结果相近 ,均一致说明 ,该疫苗的流行病学效果较理想。研究结果还显示 ,该疫苗对异血清群钩体也有一定的保护作用。
In order to evaluate the epidemiological effect of domestic leptospiral vaccine, in the period from June to October 1998, cohort studies and case-control studies were used to compare and evaluate the effects of levodopa vaccine Group and control group incidence of hook body. Cohort studies showed that the protective rate of the hooked outer membrane vaccine against leptospira was 75.17% and the effect index was 403. The vaccine-protection ratio of 1: 2 paired survey was 81 2 5%, and the 1: 3 paired result was 73 33%. Vaccine efficacy estimated by screening was 75%. The results of different research methods are similar and consistent, indicating that the vaccine’s epidemiological effect is more satisfactory. The results also show that the vaccine also has a protective effect on the leptospira interrogans.