有资料显示,支气管哮喘的发病机制与炎性细胞受激发并释放多种炎症介质,而导致哮喘。其炎性细胞包括嗜酸性细胞(Eos)、嗜碱性细胞(Bas)和肥大细胞(MC)、T细胞、MΦ等。这些细胞的激发受多种细胞因子影响,其中白细胞介素—4的中心地位不可忽视。本文从支气管哮喘发生的多个环节中如IgE的产生影响因素,嗜酸性细胞、嗜碱性细胞、MΦ、T细胞释放产生细胞因子等方面阐述了白细胞介素—4的作用,揭示了白细胞介素—4对支气管哮喘的调控作用是多方面的,并且白细胞介素—4的产生和释放也同样受其它细胞、细胞因子的影响。 Data show that the pathogenesis of bronchial asthma and inflammatory cells are stimulated and release a variety of inflammatory mediators, leading to asthma. Its inflammatory cells include eosinophils (Eos), basophils (Bas) and mast cells (MC), T cells, MΦ and so on. The stimulation of these cells is affected by a variety of cytokines, of which the central position of interleukin-4 can not be ignored. This article describes the role of interleukin-4 in various aspects of the occurrence of bronchial asthma such as IgE production factors, eosinophils, basophils, MΦ, T cell release of cytokines, revealing the role of interleukin The regulation of bronchial asthma -4 is multifaceted, and the production and release of interleukin-4 is also influenced by other cells and cytokines.