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目的:观察大蒜素对非酒精性脂肪性肝病(NAFLD)模型大鼠的治疗作用,并探讨其作用机制。方法:72只雄性SD大鼠,随机分为正常对照组、模型对照组、非诺贝特组(50mg/kg),大蒜素组(10mg/kg、30mg/kg、60mg/kg),采用高脂饮食法诱导构建NAFLD大鼠模型。非诺贝特组、大蒜素组分别灌喂相应浓度药物,正常对照和模型对照灌喂等体积生理盐水,药物干预4周后处死动物,检测各组大鼠血清空腹血糖(FBG)、放射免疫法检测胰岛素(FINS)、总胆固醇(TG)、甘油三酯(TC)、炎症细胞因子(TNF-α、IL-6、IL-10)、丙二醛(MDA)、超氧化物歧化酶(SOD)等指标水平的变化。结果:与模型对照比较,大蒜素10mg/kg、30mg/kg、60mg/kg剂量均可显著降低血清FBG、FINS、TG、TC、TNF-α、IL-6、IL-10、MDA水平,明显升高血清IL-10、SOD水平。结论:大蒜素对高脂饮食诱导的NAFLD大鼠模型具有一定的保护作用,其机制可能与其调节炎症细胞因子平衡和降低氧化应激水平有关。
Objective: To observe the therapeutic effect of allicin on nonalcoholic fatty liver disease (NAFLD) in rats and its mechanism of action. Methods: Seventy-two male SD rats were randomly divided into normal control group, model control group, fenofibrate group (50mg / kg), allicin group (10mg / kg, 30mg / kg, 60mg / kg) Fat diet induced induction of NAFLD rat model. The fenofibrate group and allicin group were fed with the corresponding concentrations of drugs, the normal control and model control were infused with equal volume of normal saline. The animals were sacrificed after 4 weeks of intervention. The fasting blood glucose (FBG), radioimmunoassay (FINS), total cholesterol (TG), triglyceride (TC), inflammatory cytokines (TNF-α, IL-6 and IL-10), malondialdehyde (MDA) and superoxide dismutase SOD) and other indicators of the level of change. Results: Compared with the model control group, allicin 10 mg / kg, 30 mg / kg and 60 mg / kg significantly reduced the level of serum FBG, FINS, TG, TC, TNF-α, IL-6, IL-10 and MDA Increase serum IL-10, SOD levels. CONCLUSION: Allicin has a protective effect on NAFLD model induced by high-fat diet. The mechanism may be related to the regulation of inflammatory cytokines and the reduction of oxidative stress.