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目的：考察不同年龄组在术后二年中各时期的环孢素 Ａ 血中谷浓度的差异，总结老年人环孢素 Ａ（ Ｃｓ Ａ） 谷浓度的特点。方法：采用荧光偏振免疫法（ Ｆ Ｐ Ｉ Ａ 法） ，对３０８ 例次肾移植（ Ｒ Ｔ） 术后二年的患者进行常规环孢素 Ａ 血药浓度谷值监测。将患者分为 Ａ、 Ｂ 两组， Ａ 组患者年龄＜ ６０ 岁； Ｂ 组患者年龄≥６０ 岁。结果：老年人在术后后期（１２ ～２４ 个月） 的谷浓度明显高于中青年组（ Ｐ＜ ０ ．０１） ；而在同组之间，６０ 岁以下患者其中、后期之间浓度差异有非常显著性（ Ｐ＜ ０ ．０１） ，老年患者其术后各个时期间谷浓度差异无显著性（ Ｐ＞ ０ ．０５） 。结论：老年人手术后期谷浓度值比中青年人高（ Ｐ＜ ０ ．０１） ，为预防环孢素 Ａ 中毒，应适当减少剂量。
OBJECTIVE: To investigate the difference of trough concentrations of cyclosporine A in different age groups in two years after operation, and to summarize the characteristics of trough concentration of CsA in the elderly. Methods: Fluorescence polarization immunoassay (F P I A) was used to monitor the plasma concentration of cyclosporine A in 308 patients who underwent renal transplantation (R T) for two years. Patients were divided into A, B two groups, A group of patients aged <60 years; B group of patients ≥ 60 years of age. Results: The trough concentrations of the elderly in the postoperative period (12-24 months) were significantly higher than those in the middle-aged and young adults (P <0.01). However, among the same group, (P <0.01). There was no significant difference in the trough concentrations between the elderly patients and the postoperative patients (P> 0.05). Conclusion: The trough concentration in postoperative elderly patients is higher than that in young adults (P <0.01). In order to prevent cyclosporine A poisoning, the dosage should be appropriately reduced.