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目的 研究低剂量１４７Ｐｍ 内照射能否改变相继高剂量６０Ｃｏγ射线引起的ＲＢＣ 损伤的适应性效应。方法 应用外周血ＲＢＣ计数、网织红细胞（ＲＣ）计数、正常染红细胞（ＮＣＥ） 微核和嗜多染红细胞（ＰＣＥ） 微核检测，观察低剂量１４７Ｐｍ 内污染诱导小鼠ＲＢＣ系统的适应性反应。结果 剂量为２ ．０Ｇｙ 的６０Ｃｏ γ射线外照射可引起明显的血ＲＢＣ 系统损伤，与正常对照组比较，ＲＢＣ和ＲＣ计数显著降低（ Ｐ＜ ０．０１） ；ＮＣＥ和ＰＣＥ微核细胞率明显增高（Ｐ＜ ０．０１） 。预先用０．３７、３ ．７ 和３７Ｂｑ／ｇ 体重的１４７Ｐｍ 内污染预处理动物，３ 天后再予２．０Ｇｙ 的高剂量６０Ｃｏ γ射线外照射，ＲＢＣ和ＲＣ计数则显著增高，ＮＣＥ和ＰＣＥ微核细胞率显著降低，与单纯高剂量６０Ｃｏ γ射线外照射组比较有非常显著性差异（Ｐ＜ ０．０１）；并且某些指标与正常对照组比较已无显著性差异（ Ｐ＞ ０．０５） 。结论 预先用低剂量１４７Ｐｍ β射线内照射动物， 可诱导血ＲＢＣ 系统的放射适应性反应，使血ＲＢＣ系统对相继高剂量６０Ｃｏ γ射线外照射引起的损伤效应有了明显的抵抗力。提示外周血ＲＢＣ 系统可作为低剂量辐射细胞生物效应的观察指标之一
Objective To investigate whether low doses of 147Pm internal irradiation can alter the adaptive effects of successive high doses of 60Coγ-rays on RBC injury. Methods Peripheral blood RBC count, reticulocyte count (RC), micronucleus test of normal red blood cells (NCE) and micronuclei of polychromatic erythrocytes (PCE) were used to detect the adaptive response of RBC system induced by low dose 147Pm contamination . The result dose is 2. OGy 60Co γ-ray irradiation can cause obvious blood RBC system injury, compared with the normal control group, RBC and RC count was significantly lower (P <0.01); NCE and PCE micronucleated cells were significantly increased (P <0. 01). Pre-use 0.37,3. 7 and 37Bq / g body weight of 147Pm contaminated pretreated animals, and then given 2.0 Gy high-dose 60Co γ-ray irradiation after 3 days, RBC and RC counts were significantly increased, NCE and PCE micronucleated cells were significantly reduced, and simple There was a significant difference between the high dose 60Co γ-ray external irradiation group and the normal control group (P <0.01). Conclusions Radiation-induced reaction of blood RBC system can be induced by pretreatment of animals with low doses of 147Pm β-rays, which makes the blood RBC system have obvious resistance to the damage caused by high-dose 60Co γ-ray irradiation. RBC system prompted the peripheral blood can be used as low dose radiation biological effects of one of the indicators