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目的探讨急性脑梗死患者同型半胱氨酸和超敏C反应蛋白检测的临床意义。方法选择2009年8月～2011年10月期间,某院神经内科收治的急性脑梗死患者102例作为研究组,另选择同期在该院进行体检的健康者154作为对照组。所有受检者均于清晨空腹采取静脉血。采用酶联免疫吸附法检测Hcy水平。采用散射化浊法检测hs-CRP的水平。分别比较两组患者、不同神经功能缺损程度患者以及不同梗死体积患者之间Hcy和hs-CRP含量的变化情况。结果与健康对照组相比,研究组患者Hcy和hs-CRP含量均明显提高,差异具有统计学意义(P﹤0.05)。与轻度神经功能缺失患者相比,中度和重度神经功能缺失患者Hcy和hs-CRP含量均明显提高,差异具有统计学意义(P﹤0.05)。与小梗死患者相比,中梗死和大梗死患者Hcy和hs-CRP含量均明显提高,差异具有统计学意义(P﹤0.05)。结论同型半胱氨酸和超敏C反应蛋白的检测对于急性脑梗死患者的早期预防和诊断具有十分重要的临床指导意义。
Objective To investigate the clinical significance of detecting homocysteine and high-sensitivity C-reactive protein in patients with acute cerebral infarction. Methods From August 2009 to October 2011, 102 patients with acute cerebral infarction admitted to the department of neurology in a hospital were selected as the study group, and 154 healthy subjects who underwent physical examination in the hospital during the same period were selected as the control group. All subjects took venous blood in fasting morning. Hcy levels were detected by enzyme-linked immunosorbent assay. The level of hs-CRP was detected by the method of scattering and turbidity. The changes of Hcy and hs-CRP levels in two groups of patients, patients with different neurological deficits and patients with different infarct volumes were compared. Results Compared with the healthy control group, the levels of Hcy and hs-CRP in the study group were significantly increased, the difference was statistically significant (P <0.05). The levels of Hcy and hs-CRP in patients with moderate and severe neurological deficits were significantly higher than those with mild neurological deficits (P <0.05). The levels of Hcy and hs-CRP in patients with middle infarction and major infarct were significantly higher than those with small infarction, the difference was statistically significant (P <0.05). Conclusion The detection of homocysteine and hypersensitive C-reactive protein plays an important clinical significance in the early prevention and diagnosis of patients with acute cerebral infarction.