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近年来一些文献中提到cGMP则涉及细胞的增生和分化.Hadden等人报告细胞分裂剂如刀豆素A和植物血凝素可引起淋巴细胞系统cGMP明显增加.此后有很多关于胸腺淋巴母细胞和纤维母细胞中cGMP刺激DNA合成的报导.银屑病、实验皮肤肿瘤、结肠腺癌、实验性肝癌、肾皮质肿瘤以及迅速生长的新生儿肾脏中cGMP含量均增高.相反地Miller等发现培养的3T3细胞生长速度下降时cGMP升高;将血清加入休止期细胞中,cAMP、cGMP两者都迅速下降.Hickie等报导在几个不同生长速度的Morris肝癌里cGMP含量与生长速度不一致.在PMA(Phorbol myristate acetate)促进实验性皮肤肿瘤增生时cGMP并不较快地(30秒到30分钟内)升高.此外使用肿瘤促成剂诱发鸟
In recent years a number of literatures mention that cGMP is involved in the proliferation and differentiation of cells.Hadden et al reported that cytokines such as concanavalin A and phytohemagglutinin can cause a significant increase of cGMP in lymphocytic system.After that there are a lot of reports about thymic lymphoblasts And cGMP in fibroblasts stimulate the synthesis of DNA in patients with psoriasis, experimental skin tumors, colon adenocarcinoma, experimental liver cancer, renal cortical tumors and rapidly growing cGMP kidneys in children were increased.On the contrary, Miller and other found that culture Of cTMP cells increased cGMP levels decreased; the serum added to the quiescent cells, cAMP, cGMP both decreased rapidly.Hickie et al reported in several different growth rates of Morris liver cancer cGMP content and growth rate inconsistent in the PMA (Phorbol myristate acetate) to promote experimental skin tumor hyperplasia cGMP does not increase rapidly (30 seconds to 30 minutes) In addition, the use of tumor-inducing agents induce birds