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目的：为探讨Ｆａｓ、Ｂａｘ基因在胃癌发生过程中的意义。方法：用免疫组化ＡＢＣ方法检测了４８例胃腺癌组织，７４例非癌胃粘膜组织。结果：重度不典型增生组织及癌组织中Ｆａｓ蛋白表达率分别为３７５％、４５８％较正常胃粘膜上皮的８２３％显著下降（Ｐ＜００５），轻、重不典型增生组织及癌组织中Ｂａｘ蛋白表达率为４２８％，５００％，４３６％较正常胃粘膜上皮的８８２％显著下降（Ｐ＜００５）。中、高分化胃癌Ｆａｓ、Ｂａｘ蛋白阳性表达率显著高于低分化癌（Ｐ＜００５）。并且Ｆａｓ与Ｂａｘ在组织中的表达呈相关性（Ｐ＜００５）。结论：Ｆａｓ、Ｂａｘ蛋白表达变化发生在胃粘膜癌变的早期阶段，并可能与癌的进展密切相关，Ｆａｓ与Ｂａｘ在胃癌发生发展中有显著的相关性。
Objective: To explore the significance of Fas and Bax genes in the development of gastric cancer. Methods: 48 cases of gastric adenocarcinoma tissue and 74 cases of non-cancerous gastric mucosa were detected by immunohistochemical ABC method. RESULTS: The expression rates of Fas protein in severe dysplasia and cancer tissues were 37.5% and 45.8%, respectively, which were significantly lower than those of 82. 3% of normal gastric epithelial cells (P < 0.05). The expression rate of Bax protein was 42.8%, 50.0%, and 43.6% in typical proliferative tissues and cancer tissues, which was significantly lower than that of 88. 2% of normal gastric epithelium (P < 0.05). The positive rate of Fas and Bax protein expression in moderately and well-differentiated gastric cancer was significantly higher than that in poorly differentiated cancer (P<005). And there was a correlation between the expression of Fas and Bax in tissues (P<005). Conclusion: The changes of Fas and Bax protein expression occur in the early stage of gastric mucosal carcinogenesis and may be closely related to the progression of cancer. Fas and Bax have a significant correlation in the development of gastric cancer.