论文部分内容阅读
研究血管内皮生长因子（ＶＥＧＦ）及其受体（ＫＤＲ）在大肠癌中的表达及其临床意义。［方法］应用免疫组化ＳＰ 法检测１５５ 例大肠癌标本ＶＥＧＦ及ＫＤＲ蛋白的表达。分析ＶＥＧＦ和ＫＤＲ与临床病理因素、微血管计数（ＭＶＣ）及预后的关系。［结 果〕ＶＥＧＦ和ＫＤＲ的表达与大肠癌浸润深度、淋巴结转移、血管侵犯、肝脏转移、Ｄｕｋｅｓ’分期密切相关，而与组织学分型和肿瘤大小 无关。ＶＥＧＦ和ＫＤＲ的表达密切相关。ＶＥＧＦ和ＫＤＲ表达阳性者ＭＶＣ显著高于阴性者。ＶＥＧＦ阳性者预后较阴性者明显为差。 ［结论］ＶＥＧＦ和ＫＤＲ与大肠癌血管生成有关，促进了大肠癌的侵袭和转移。 ＶＥＧＦ是大肠癌病人一个较好的预后指标。
To study the expression of vascular endothelial growth factor (VEGF) and its receptor (KDR) in colorectal carcinoma and its clinical significance. [Method] Immunohistochemical SP method was used to detect the expression of VEGF and KDR protein in 155 cases of colorectal cancer. The relationship between VEGF and KDR and clinicopathological factors, microvessel count (MVC) and prognosis was analyzed. [Results] The expressions of VEGF and KDR were closely related to the depth of invasion, lymph node metastasis, vascular invasion, liver metastasis and Dukes’ stage in colorectal cancer, but not with histological type and tumor size. The expression of VEGF and KDR are closely related. MVC was significantly higher in patients with positive expression of VEGF and KDR than in negative patients. The prognosis of VEGF-positive patients was significantly worse than negative. [Conclusion] VEGF and KDR are involved in the angiogenesis of colorectal cancer and promote the invasion and metastasis of colorectal cancer. VEGF is a good prognostic indicator for patients with colorectal cancer.